Electric signaling pathways are important for rapid and long-distance communication within a plant.Changes in the electric potential (EP) inside plants have been observed during the propagation of electric signals.Increasing radiofrequency electromagnetic radiation (EMR) in the environment raise the question about possible effects of EMR on the EP
Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe.
The dynamics of four regions of tropomyosin was assessed using saturation transfer electron paramagnetic resonance in the muscle fiber.In order to fully immobilize the spin probe on the surface of tropomyosin, a bi-functional spin label was attached to i,i+4 positions via cysteine mutagenesis.The dynamics of bi-functionally labeled tropomyosin muta
Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS
Introduction: Malignant pleural mesothelioma (MPM) is a malignancy with a very poor prognosis for which new treatment options are urgently needed.We have previously shown that dendritic cell (DC) immunotherapy provides Bikini a clinically feasible treatment option.In the current study, we set out to assess the immunological changes induced by DC im
A method for approximating optimal statistical significances with machine-learned likelihoods
Abstract Machine-learning techniques have become fundamental in high-energy physics and, for new physics searches, it is crucial to know their performance in terms of experimental sensitivity, understood as the statistical significance of the signal-plus-background hypothesis over the background-only one.We present here a simple method that combine